Anti-Fibrinolytic: Difference between revisions
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* Inhibits both plasminogen activation and plasmin activity, thus preventing clot break-down rather than promoting new clot formation. With massive bleeding this may help stabilize clot formation and decrease extravascular bleeding. | * Inhibits both plasminogen activation and plasmin activity, thus preventing clot break-down rather than promoting new clot formation. With massive bleeding this may help stabilize clot formation and decrease extravascular bleeding. | ||
'''INDICATIONS''' | '''INDICATIONS''' | ||
* [[Shock|Severe Hemorrhagic Shock]]. | * [[Hemorrhagic Shock|Severe Hemorrhagic Shock]]. | ||
*Strongly consider in non-traumatic bleeding (post-partum, gastrointestinal, postoperative, nasal) | |||
'''PREGNANCY CATEGORY''' | |||
* B - Safe in Pregnancy | |||
* Safe in breastfeeding | |||
'''CONTRAINDICATIONS''' | '''CONTRAINDICATIONS''' | ||
* | * Hypersensitivity to TXA | ||
* | * Colorblindness | ||
* | * History of Seizures | ||
* | * Ischemic event: Myocardial Infarction, stroke, pulmonary embolism (PE), deep venous thrombosis (DVT) | ||
* Isolated head injury / subarachnoid hemorrhage | |||
'''PRECAUTIONS''' | '''PRECAUTIONS''' | ||
* Rapid injection can cause hypotension | * Rapid injection can cause hypotension | ||
'''DOSAGE''' | '''DOSAGE''' | ||
* 1000 mg of TXA mixed in 100 ml or 250 ml of normal saline infused via IO or IV over 10 minutes. | * 1000 mg of TXA mixed in 100 ml or 250 ml of normal saline infused via IO or IV over 10 minutes. | ||
* 20mg/kg (1000mg maximum) TXA mixed in 100 ml of Normal Saline infused via IO or IV over 10 minutes. | |||
[[Category:Medication Guidelines|0819]] | [[Category:Medication Guidelines|0819]] | ||
Latest revision as of 19:21, 10 July 2019
Section 8 - MEDICATION GUIDELINES
8.19 ANTI-FIBRINOLYTICS
Tranexamic Acid (TXA)
DESCRIPTION
- Inhibits both plasminogen activation and plasmin activity, thus preventing clot break-down rather than promoting new clot formation. With massive bleeding this may help stabilize clot formation and decrease extravascular bleeding.
INDICATIONS
- Severe Hemorrhagic Shock.
- Strongly consider in non-traumatic bleeding (post-partum, gastrointestinal, postoperative, nasal)
PREGNANCY CATEGORY
- B - Safe in Pregnancy
- Safe in breastfeeding
CONTRAINDICATIONS
- Hypersensitivity to TXA
- Colorblindness
- History of Seizures
- Ischemic event: Myocardial Infarction, stroke, pulmonary embolism (PE), deep venous thrombosis (DVT)
- Isolated head injury / subarachnoid hemorrhage
PRECAUTIONS
- Rapid injection can cause hypotension
DOSAGE
- 1000 mg of TXA mixed in 100 ml or 250 ml of normal saline infused via IO or IV over 10 minutes.
- 20mg/kg (1000mg maximum) TXA mixed in 100 ml of Normal Saline infused via IO or IV over 10 minutes.